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KMID : 1011220140010020045
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Clinical & Experimental Thrombosis and Hemostasis
2014 Volume.1 No. 2 p.45 ~ p.53
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Remnant Lipoproteins: A Subfraction of Plasma Triglyceride-Rich Lipoproteins Associated with Postprandial Hyperlipidemia
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Nakajima Katsuyuki
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Abstract
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Plasma remnant lipoproteins, a subfraction of triglyceride (TG)-rich lipoproteins (TRLs), have been shown to be a causative factor for atherosclerosis and thrombosis. TRLs are rich in chylomicrons (CM), very low-density lipoproteins (VLDL) and their remnants (partially metabolized CM and VLDL). Remnant lipoproteins are significantly increased in the postprandial plasma and are predictive of the risk for coronary heart disease (CHD), independent of the total cholesterol, TG, LDL-C or HDL-C. The biochemical and physiological characteristics of remnant lipoproteins are very similar to that of oxidized LDL (ox-LDL), but the plasma concentrations of ox-LDL are extremely low compared with concentrations of remnant lipoproteins. The isolation of remnant lipoproteins from plasma has been difficult for a long time because ultracentrifugation and electrophoresis, the most common methods for the isolation of lipoprotein fractions, can’t specifically isolate remnant lipoproteins. The immuno-separation method enables specific isolation of remnant lipoproteins from plasma as an unbound fraction to the anti-apoB100 and apoA-1 immuno-affinity gel. Using this technique, an easy remnant lipoprotein-cholesterol assay (RLP-C) can be performed to investigate the clinical significance of remnant lipoproteins in the plasma. Over the last two decades, this immune-separation technique has provided new insights into remnant lipoproteins.
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KEYWORD
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Postprandial lipoproteins, Chylomicron (CM) remnants, Very low density lipoprotein (VLDL) remnants, Remnant lipoprotein-cholesterol (RLP-C), Oxidized-LDL (Ox-LDL)
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